Quantitative detection of the diabetic retinopathy-associated microRNA-1281 via a CRISPR/Cas12a-RCA ratiometric sensing platform.
Diabetic retinopathy (DR) is a major microvascular complication of diabetes, yet accessible molecular tools for early-stage screening remain limited. Circulating microRNAs are promising non-invasive biomarkers for DR, but their reliable quantification in serum is hindered by low abundance, matrix interference, and limi...