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Author

Pei-Wu Geng

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Oct 2026

Drug-drug interaction between vonoprazan and imatinib: in vivo pharmacokinetics and in vitro metabolic inhibition characterization.

1. Vonoprazan and imatinib may be co-prescribed in patients with acid-related disorders, but the pharmacokinetic consequences of this combination remain unclear.2. We evaluated the effects of vonoprazan on imatinib pharmacokinetics in rats and compared metabolic inhibition in human and rat liver microsomes.3. Rats (n =...

Fei Dai, Yu Wang, Pei-Wu Geng et al. · 0 citations
Open access Oct 2026

Oleanolic Acid-Loaded Organosilica Nanoparticles for Synergistic Anti-Inflammatory and Antibacterial Therapy via Inducing Macrophage Polarization

Chronic inflammatory diseases caused by bacterial infections are notoriously difficult to treat due to the formation of a vicious cycle in which bacterial infection and immune dysregulation mutually reinforce each other at the lesion site. Current antibiotic therapies face the dual challenges of escalating drug resis...

Xiao-Peng Zhou, Hua-Fu Wang, Shuang-Hua Wang et al. · 0 citations

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