MOLECULAR-MORPHOLOGICAL DISSOCIATION IN VITRIFIED-WARMED HUMAN EMBRYOS: RETHINKING EPIGENETIC RISK BEYOND MORPHOLOGY
Although vitrification has transformed assisted reproductive technology, it occurs during a critical developmental window characterized by extensive epigenetic remodeling and transcriptional recalibration; freeze-thaw procedures expose gametes and embryos to osmotic, cryoprotectant, oxidative, and mitochondrial stress,...