Peng An

Fibroblast activation protein-α in liver fibrosis and hepatocarcinogenesis: Stromal remodeling, molecular imaging, and theranostic targeting.

Liver fibrosis links chronic liver injury to cirrhosis, hepatic decompensation, and hepatocellular carcinoma (HCC), while current non-invasive tests mainly estimate fibrotic burden and incompletely capture active stromal biology. Fibroblast activation protein-α (FAPα), a cell-surface serine protease enriched in activat...

Post-translational modification crosstalk in acute pancreatitis: linking acinar stress to innate immune amplification and tissue repair

Acute pancreatitis (AP) is a sterile inflammatory disease initiated by acinar cell stress and amplified through innate immune, vascular, and inter-organ responses, yet effective disease-modifying therapies remain unavailable. Although premature digestive enzyme activation, organelle stress, sterile inflammation, and mi...

USP2-Mediated Deubiquitination of β-catenin Drives Colorectal Adenocarcinoma Progression and Immune Evasion.