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Open access Sep 2026

Recombinant B87 and HLJ0504 VP2 Vaccines Protect Chickens Against Infectious Bursal Disease

Infectious bursal disease virus (IBDV) causes immunosuppression and bursal damage in chickens, and safer recombinant vaccines that provide durable protection are needed. This study compared the antigenicity, immunogenicity, protective efficacy, safety and antibody persistence of unpurified VP2 preparations and purified...

Tayyab Ali Asif, Peng Chen, Jia-Hao Li et al. · 0 citations
Sep 2026

Co-administration of a chicken interleukin-2-interferon-α fusion protein enhances immune responses and protective efficacy of an inactivated fowl adenovirus serotype 4 vaccine.

Hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) poses a severe threat to global poultry production. Although inactivated vaccines are widely used, they may elicit suboptimal cellular immune responses and provide incomplete protection. In this study, six candidate immunostimulants were comp...

Peng Chen, Yanan Cui, Longhai Ji et al. · 0 citations

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