Open access
Sep 2026
ERa-induced m6A reader HNRNPC maintains DDX6 mRNA stability to promote tumor progression in ER+BC.
An ERα/HNRNPC/DDX6 axis in ER+ breast cancer is unveiled, wherein ERα transcriptionally upregulates HNRNPC, which in turn stabilizes DDX6 mRNA in an m6A-dependent manner to drive tumor progression, suggesting HNRNPC as a promising therapeutic target.
Zi-Wei Huang, Wen-Jie Xu, Yun-Xiao Xiao et al.
· British Journal of Cancer · 0 citations