Peng-Guang Wu

Helical Peptidomimetic Inhibitors Targeting the Histone Chaperone ASF1 for Cancer Therapy

Targeting protein−protein interactions (PPIs) with shallow, extended interfaces remains challenging, as exemplified by the histone chaperone ASF1. Here, we report de novo designed d-sulfonyl-γ-AApeptide foldamers that mimic the hot-spot residues of the histone H3 C-terminal α-helix that are essential for ASF1 recogni...