Open access
Jul 2026
Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease
ABSTRACT A major challenge in RNA therapeutics for central nervous system disorders is the lack of delivery systems capable of crossing the blood–brain barrier (BBB) while achieving cell‐type‐specific targeting. Herein, we develop an engineered exosomal siRNA delivery platform for systemic, neuron‐targeted RNA transpor...
Chi Zhang, Jiaqi Zhang, Yuzhi Wang et al.
· Advancement of science · 0 citations