Peng Liu

A binuclear copper enzyme platform for enantioconvergent radical (pseudo)halogenation

Despite their intriguing native metalloenzymology, naturally occurring copper enzymes remain largely underexploited for new-to-nature biocatalytic reactions. Herein, we report the systematic investigation and reprogramming of natural copper enzymes to catalyze unnatural free radical (pseudo)halogenation reaction in a h...

Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes.

Directed Evolution of Nonheme Fe Enzymes for Enantioselective and Regiodivergent 1,3- and 1,4-Nitrogen Migration: Biocatalytic Asymmetric Synthesis of Noncanonical α- and β-Amino Acids.

Two complementary nitrogen migratases were developed that enabled biocatalyst-controlled 1,3- and 1,4-nitrogen migration with excellent regioselectivity and exhibited similar kinetic isotope effects for both 1,5- and 1,6-HAT pathways, suggesting that enzyme engineering controls regio- and enantioselectivity but does no...