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Author

Peng Lu

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Open access Oct 2026

Molecular mechanism of SIRT1 activation by polymethoxyflavonoids derived from citrus peels.

Sirtuin 1 (SIRT1) activation by small molecules is linked to aging-related health benefits. We investigated how citrus peel-derived polymethoxyflavonoids (PMFs), 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) and 5,6,7,8,3',4'-hexamethoxyflavone (nobiletin), activate SIRT1. Both compounds modestly but reproducibly increased...

D. Warman, Koh Takeuchi, Sayaka Okonogi et al. · 0 citations

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