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Review Open access Aug 2026

Resistance mechanisms and countermeasures in CLDN18.2-positive tumors: from molecular networks to clinical practice

Claudin 18.2 (CLDN18.2) has rapidly become a major target in solid-tumor oncology. Zolbetuximab, the first anti-CLDN18.2 antibody, was approved in 2024 for HER2-negative, CLDN18.2-high advanced gastric and gastro-esophageal junction adenocarcinoma, and more than one hundred CLDN18.2-directed trials are now under way ac...

Yu-Tao Xia, Ming-Fang Wang, Tao-Sheng Huang et al. · 0 citations
Open access Aug 2026

Osimertinib With or Without Chemotherapy in Advanced Non-Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations: A Randomized Clinical Trial.

Importance Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients most likely to derive benefit from such...

Ting Zhou, Huaqiang Zhou, Fangfang Gao et al. · 1 citation

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