Author

Pengyu Ren

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Aug 2026

High-Throughput On-Chip Screening Enables Rapid Adaptation of DNA Aptamers to SARS-CoV-2 Evolution.

A high-throughput aptamer engineering platform that combines a random-rational hybrid library diversification with repurposed MiSeq screening to rapidly reprogram aptamers against emerging SARS-CoV-2 spike variants is demonstrated, demonstrating a rapid and sequence-resolved aptamer engineering platform for adapting ap...

Yu-Jie He, Zhenglin Yang, Yu-An Kuo et al. · ACS Nano · 0 citations

Open access Aug 2026

Transmembrane coupling of protein condensates via membrane-mediated interactions: A simulation study

The results indicate that the coupling is driven mainly by curvature, and that it depends on the wetting mechanism and on the membrane tension.

B. R. Argun, Jeanne C. Stachowiak, Peng-Yu Ren · bioRxiv · 0 citations

Open access Jul 2026

Incorporating a neural network into the AMOEBA polarizable force field for ligand field effects of Cu2+ ions

AMOEBA + NN, a machine-learning-augmented polarizable potential, is presented, to investigate Cu2+ solvation in NH3 and H2O and mixed environments and provides a unified, computationally efficient framework for describing the structural, dynamic, and thermodynamic observables of transition metal coordination.

Zhecheng He, Yanxing Wang, Shubham Chatterjee et al. · Chemical Science · 0 citations