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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Peng Zhan

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Open access Sep 2026

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights

Abstract This highlight summarizes the recent advances in cereblon (CRBN) substrate discovery and mechanisms of action within the field of molecular glues. It emphasizes that molecular glue technology has transitioned from the stage of monofunctional targeted protein degradation to that of rational design and multidime...

Qing-Yun Guan, Xiao-Yu Shi, Qian Yang et al. · 0 citations
Editorial Open access Jul 2026

Novel Mechanisms of SARS-CoV-2 Drug Resistance and Rational Design of Anti-Resistant Antivirals

Three effective countermeasures have been established: structure-based optimization of Mpro inhibitors, rational design of ExoN-evading nucleoside analogues, and synergistic combination therapies to combat emerging resistant SARS-CoV-2 variants.

Xianghan Bai, Bing Ye, Sheng-Hua Gao et al. · 0 citations
Jul 2026

Targeted Degradation of Capsid by Host-Hijacking PROTAC Overcomes Drug Resistance.

This work pioneers the development of CA-targeted degraders, providing a framework for next-generation anti-HIV therapies with high potency and resistance barriers, via a proteasome-driven pathway.

Mei Wang, Ze-Yu Peng, Yang Zhou et al. · 0 citations

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