Peng Zhou

An orally administered peptide hydrogel disentangles immune-microbiota crosstalk for long-term ulcerative colitis therapy

Ulcerative colitis (UC) is a global health challenge driven by immune dysregulation and gut microbiota imbalance.1 Current treatments, limited by insufficient efficacy and systemic toxicity during prolonged use, fail to resolve the intertwined immune-microbial pathology.2 Here, we report an orally administered self-ass...

Correction to "Mapping Free-Energy Landscapes to Decipher Amphiphilic Peptide Multistep Self-Assembly".

In Silicon Deciphering Atomic-Scale Structural Units in Peptide Glass.

Peptide glasses are an emerging class of biofunctional amorphous materials, but their atomic-level structure has remained elusive. Here, we resolve the three-dimensional (3D) organization of peptide glasses using a cyclic dipeptide model, combining molecular dynamics simulations with 2D solid-state NMR fingerprinting....

Mapping Free-Energy Landscapes to Decipher Amphiphilic Peptide Multistep Self-Assembly.

The formation of fibrous architectures via peptide self-assembly underpins numerous biological functions and biomaterial applications; however, the thermodynamic origins of multistep assembly pathways remain elusive. Here, we map the complete free-energy landscape governing the liquid-liquid phase separation (LLPS)-med...