Review
Open access
2021
Insulin physiology and metabolic control: current concepts and perspectives
Type 2 diabetes (T2D) results from progressive failure of multiple interconnected metabolic nodes. This review synthesizes evidence that β-cell dedifferentiation, mediated by loss of PDX-1, MAFA, and NKX6.1 and by epigenetic silencing of their promoters, may represent a leading mechanism of β-cell dysfunction, potentia...
Cozar-Castellano Irene, L. Astrid, Perdomo German et al.
· Metabolism and Target Organ... · 0 citations