Open access
Jul 2026
Leishmanial GP63 acts as a protease for the small pore forming toxin aerolysin
The L. major virulence factor lipophosphoglycan defends against pore-forming toxins made by bacterial competitors, while the GP63 metalloproteinase activates pro-aerolysin like furin to protect L. major from aerolysin cytotoxicity.
Chaitanya S. Haram, Sebastián Salinas, Salma Waheed Sheikh et al.
· bioRxiv · 0 citations