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Author

Peter B. Stathopulos

2 papers indexed here

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Open access Oct 2026

Phosphorylation of the mitochondrial calcium uniporter beta subunit matrix domain locks a conformation that suppresses mitochondrial calcium flux.

Mitochondrial calcium (Ca2+) uptake is a central regulator of metabolism, signal transduction and cell death pathways. The mitochondrial calcium uniporter complex (mtCU) mediates this flux through a tetrameric pore comprised of MCU and MCU beta (MCUb) subunits. The large, matrix-oriented amino (N)-terminal domains (NTD...

Danielle M. Colussi, Zoya Lehman, Da-Lang Zhuang et al. · 0 citations
Open access Aug 2026

Prohibitin controls MRS2-Mediated mitochondrial Mg2+ uptake to Shape bioenergetics

SUMMARY Mitochondrial magnesium (mMg2+) is essential for cellular metabolism and bioenergetics, yet the mechanisms governing its transport remain poorly understood. Although MRS2 constitutes the pore of the mMg2+ channel, the molecular machinery regulating its function is unknown. Here, unbiased proteomics identified t...

Soumya Maity, Manigandan Venkatesan, Adhishree Chidambaram et al. · 0 citations

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