Sep 2026
VIPR RNA-guided DNA recognition by noncontiguous geometric triplex formation.
Peter H. Yoon, Trevor A. Docter, Z. Zhang et al.
· Science · 0 citations
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Sep 2026
A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas.
The discovery of Viral Interference Programmable Repeat systems consisting of a Vipr protein ancestral to the earliest CRISPR-Cas effectors and VIPR RNAs (vrRNAs) comprising alternating GGY/NN motifs suggests that adaptive immunity originated from ancient warfare between viruses.
Peter H. Yoon, Kenneth J. Loi, Z. Zhang et al.
· Science · 2 citations
Open access
Jul 2026
Structure and evolution-guided design of minimal RNA-guided nucleases
A protein design strategy is used that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent variants of TnpB, a minimal CRISPR-Cas12-like nuclease, termed SynTnpBs, establishing a strategy for creating non-natural RNA-guided nucleases and conformatio...
Petr Skopintsev, Isabel Esain-Garcia, Evan C. DeTurk et al.
· Science · 2 citations