Open access
Jul 2026
VirD4 coupling proteins suppress accumulation of conjugative pili produced by type IV secretion systems
It is proposed that the binding of a cognate DNA substrate triggers the T4CP to suppress pilus production by blocking elongation, or stimulating retraction or release, which transitions the T4SS from its default pilus-generating (mate-seeking) mode to the activated DNA-translocation (mating) machine.
Pratick Khara, E. Hancock, Kouhei Kishida et al.
· mBio · 0 citations