Author

Peter Kuhn

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Open access Sep 2026

The Landscape of Tumor Dissemination in Leptomeningeal Disease: Mapping CTC Plasticity and Regional Heterogeneity Across Blood and CSF Compartments

Background/Objectives: Leptomeningeal disease (LMD) is among the most severe complications of metastatic breast cancer, with median survival measured in weeks. Definitive diagnosis relies on neuroimaging and cerebrospinal fluid (CSF) cytology, which carries a false-negative rate of 40–50% at a single lumbar puncture. I...

Stephanie N. Shishido, Baishali Chaudhuri, Vidur Mushran et al. · Cancers · 0 citations

Open access Sep 2026

Enrichment-Free Rare Cell Profiling in Pediatric Osteosarcoma Reveals a Circulating Cell Population Associated with Relapse-Free Survival

Background: Outcomes for patients with osteosarcoma (OS) presenting with metastases at diagnosis or relapsed remain poor with five-year survival rate of only 20–30%. Risk stratification at diagnosis remains limited, and no validated prognostic liquid biopsy analyte currently exists for this disease. OS lacks the recurr...

Stephanie N. Shishido, Siddhant Chaudhary, Ian Ward et al. · Cancers · 0 citations