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Author

Peter Rehling

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Open access Aug 2026

Guanosine 10 methylation by TRMT11–TRMT112 optimizes human mitochondrial tRNAs for efficient translation

Abstract Modified nucleotides are essential determinants of RNA function, and identifying the enzymes that install them is fundamental to understanding their cellular roles. Here, we show that the human RNA methyltransferase TRMT11 and its cofactor TRMT112 are imported into mitochondria via N-terminal targeting signals...

Jonny Petrosyan, Mehmet Yilmaz, Carolin P. M. Scheitl et al. · 0 citations
Review Open access Aug 2026

Adaptation of OXPHOS biogenesis to cellular requirements

Metabolic cues regulate the formation of the mitochondrial OXPHOS machinery. These regulatory processes are tightly linked to mitochondrial translation, proteolytic degradation of unassembled subunits, and the formation of supercomplexes, creating checkpoints at which nutrient availability, oxygen tension, and signalin...

Sven Dennerlein, Peter Rehling · 0 citations

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