Author

Peter Stockinger

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Open access Sep 2026

Iterative and data-driven ortholog mining enables reliable discovery of stereoselective ketoreductases

Ketoreductases (KREDs) enable stereoselective alcohol synthesis and are widely used industrially. Yet identifying process-compatible and selective enzymes for non-native substrates remains challenging, requiring extensive screening. Here, we present an iterative ortholog mining strategy to explore functional space....

Peter Stockinger, M. Niklaus, Kevin M. Yar et al. · Nature Communications · 0 citations

Open access Jul 2026

A tailored CoA ligase–N-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope

DNA-encoded chemical library (DEL) technology is a powerful tool in early-stage drug discovery. Although widely applied in industry and academia, challenges persist in generating DELs with high quality and chemical diversity. Low yields in building-block incorporation, limited selectivity and, most importantly, DNA dam...

Daniel Schaub, Alice Lessing, Fabian Meyer et al. · Nature Catalysis · 1 citation