Petr Broz

When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome

Recent studies have provided new insights into the molecular basis of LPS recognition by the caspase-4/11 CARD, including its interactions with LPS and other lipid ligands, the evolutionary origins of inflammatory caspases, the structural organization of LPS-caspase complexes, and the regulatory mechanisms that govern...