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Author

Petr Pecina

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Open access Aug 2026

Polyunsaturated fatty acid sequestration protects against mitochondrial dysfunction-induced ferroptosis

It is shown that cells with OXPHOS deficiencies accumulate triacylglycerols enriched in polyunsaturated fatty acids (PUFAs), which are stored in lipid droplets, which reveal a novel protective mechanism against ferroptosis, which preserves membrane integrity against lipid peroxidation-driven ferroptosis.

G. Puertas-Frías, María José Saucedo-Rodríguez, Kristýna Čunátová et al. · 0 citations
Review Open access Aug 2026

Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease

Findings establish the physiological relevance of the LSP2 promoter, support routine assessment of the mitochondrial genome in inherited kidney disease, and highlight mtDNA variants as an important cause of familial and sporadic tubulointerstitial kidney disease of previously unexplained etiology.

K. Svojšová, K. Kidd, Dita Mušálková et al. · 0 citations

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