Petro O. Borysko

Structure-activity relationship of drug-derived molecules containing spirocyclic azetidine or 2,4-methanopyrrolidine moiety

Local structural modification of approved drugs is a productive route in medicinal chemistry. If the parent molecule has already undergone pharmacological validation, the replacement of a single moiety can alter its solubility, metabolic stability, or some other properties, without altering the remaining essential char...