Author

Peyton C. High

2 papers indexed here

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Review Open access Sep 2026

Advances in Bispecific Antibodies and Antibody–Drug Conjugates for Colorectal Cancer Treatment

Bispecific antibodies (bsAbs) and bispecific antibody–drug conjugates (bsADCs) represent promising classes of emerging targeted therapeutics with the potential to overcome tumor heterogeneity and resistance in colorectal cancer (CRC). BsAbs can simultaneously engage multiple tumor antigens or immune cells or bind two d...

Maya G. Cappellino, Sean P. Sullivan, Peyton C. High et al. · Antibodies · 0 citations

Open access Aug 2026

Antibody-drug conjugate combination therapy targeting LGR5 and MET with different payloads enhances efficacy in preclinical colorectal cancer models

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a marker of cancer stem-like cells frequently upregulated in colorectal cancer (CRC) with lower expression in normal tissues, making it a favorable target for antibody-drug conjugates (ADCs). ADCs combine antibody specificity with potent cytotoxic pa...

Shraddha Subramanian, Peyton C. High, Cara Guernsey-Biddle et al. · bioRxiv · 0 citations