Author

Phi T. Nguyen

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Open access Sep 2026

Spatial Proteomics and Epigenomics Reveal Cell Morphology and Epigenetic Gene Regulation in Human Hippocampus

Abstract We present the first spatial tri-omic (proteomic, transcriptomic, and epigenomic) taxonomy of human hippocampus, addressing two key challenges in single-cell and spatial transcriptomics: visualizing cell morphology and epigenetic gene regulation in situ. By designing and multiplex imaging a novel panel of 25 p...

Rong Fan, Yang Xiao, Graham Su et al. · Research Square · 0 citations

Open access Aug 2026

Dysregulated adult hippocampal neurogenesis in major depressive disorders.

A neurogenic lineage in the adult human hippocampal subgranular zone is identified and evidence for a stalled neurogenic process in MDD is provided, associated with transcriptional regulation, stress-related reprogramming and interferon signaling across developmental stages.

Madeleine S Peng, Jia-Jia Jiang, Luciana Polizzi et al. · Nature Medicine · 2 citations