Author

Philipp Keyl

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Open access Oct 2026

Matched primary-metastasis single-nucleus and spatial profiling of leiomyosarcoma identifies antigen-presenting fibroblasts at the tumor-organ interface

Leiomyosarcoma is an aggressive soft tissue sarcoma that metastasizes preferentially to lung and liver. Because matched primary and metastatic specimens are rarely available, the cellular changes that accompany metastatic progression remain poorly defined. Here we combined single-nucleus RNA sequencing of archival FFPE...

Anna Kübler, L. Bergmayr, T. Knösel et al. · bioRxiv · 0 citations

#artificial intelligence Preprint Aug 2026

LUCAID: Agentic Multimodal AI for Lung Cancer Precision Pathology

LUCAID is an agentic AI system for precision lung cancer pathology that combines diagnostic reasoning with nine modules that cover the full routine workflow, from quality control, tumor detection and segmentation, histological subtyping, tumor microenvironment profiling, tumor cellularity quantification, and predictive...

M. Eich, K. Standvoss, Timo Milbich et al. · 0 citations