Author

Phillip Scott

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Review Sep 2026

Beyond the parasite: skin-intrinsic cytolytic circuits drive disease in cutaneous leishmaniasis and reveal targets for host-directed therapy

SUMMARY Cutaneous leishmaniasis (CL) is a globally prevalent parasitic disease in which tissue pathology often arises primarily from immune-mediated damage rather than uncontrolled parasite replication. Despite effective Th1 responses and the production of IFN-γ, lesions often fail to resolve, highlighting an uncouplin...

Fernanda O. Novais, Phillip Scott · Microbiology and Molecular B... · 0 citations

Open access Sep 2026

IL-1α protects intestinal barrier in murine visceral leishmaniasis

ABSTRACT Interleukin-1 (IL-1) is a pleiotropic cytokine important in inflammatory and infectious diseases, but its roles in visceral leishmaniasis (VL) remain poorly understood. Here, we evaluated the role of IL-1 cytokines during experimental visceral leishmaniasis. We showed that IL-1 receptor 1 (IL-1R1) deficiency e...

L. A. Sacramento, P. A. Sampaio, Gabriela Castilho Martins et al. · mBio · 0 citations

#software testing Open access Aug 2026

Volatile Organic Compounds as In Vitro Biomarkers of Leishmania major

The in vitro VOC profile of Leishmania major represents a metabolic fingerprint of parasite activity and highlights candidate biomarkers with diagnostic potential and support further investigation of VOC-based tools for automated culture detection and noninvasive diagnosis in resource-limited settings.

Alex Green, A. Zabala, Phillip Scott et al. · Journal of the Pediatric Inf... · 0 citations