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Pihu Mehrotra

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Open access Sep 2026

Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries

Arteries are among the first tissues to exhibit age-related dysfunction, yet the metabolic mechanisms driving vascular senescence remain poorly understood. Here, analysis of human aortic transcriptomic data identified HCAR1, encoding the lactate receptor GPR81, as one of the genes most significantly downregulated with...

Yu-Lun Wu, Hamsa Vardini Senthil Kumar, Sai Harsha Bhamidipati et al. · 0 citations
Open access Aug 2026

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

It is reported that loss of the lactate receptor GPR81 in cellular and progeroid models of muscle aging is associated with impaired lipid oxidation and enhanced lipid accumulation, and agonists of GPR81 might play a promising role in reversing age‐associated lipid accumulation and loss of muscle function.

Pihu Mehrotra, Sai Harsha Bhamidipati, P. Lei et al. · 0 citations

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