Pin-Yuan Chen

3D bioprinted silk fibroin- and hyaluronic acid-based biomimetic extracellular matrices with tunable stiffness regulate glioblastoma invasion and macrophage polarization.

Glioblastoma (GBM) is a highly aggressive brain tumor characterized by rapid proliferation and extensive infiltration, severely limiting the efficacy of surgical resection. Biomimetic in vitro models that recapitulate the tumor extracellular matrix (ECM), particularly the hyaluronic acid (HA)-rich ECM and stiffness-ass...