Curation of Gene-Protein-Reaction Associations Enhances the iPichia Genome-Scale Metabolic Model of Komagataella phaffii.
Komagataella phaffii is a commercially valuable yeast widely used in biotechnology due to its Crabtree-negative metabolism, which enables it to sustain respiratory growth and efficiently utilize carbon sources even in the presence of excess glucose. To better understand and predict its metabolic behavior, genome-scale...