Ping An

BKV activates the interferon-β response in primary and immortalized microvascular endothelial cells late in the infectious cycle, resulting in persistence

ABSTRACT Our previous studies have shown that inoculation of primary endothelial cells with BKV results in a long-term persistent infection, with inoculated cultures surviving up to 60 days while producing low levels of infectious viral progeny. Unlike the permissive renal proximal tubule cells, infected endothelial ce...