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Author

Ping Gong

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2 papers indexed here

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Sep 2026

Design and development of novel, potent and brain penetrant cyclic LRRK2 inhibitors for the treatment of Parkinson's disease.

Parkinson's disease (PD) is a debilitating and progressive neurodegenerative disorder, where disease-modifying therapy (DMT) represents a major unmet clinical need. Advances in the understanding of underlying pathogenesis reveal the potential therapeutic value of inhibitors targeting leucine-rich repeat kinase 2 (LRRK2...

Wen-Qing Xu, Tian-Qiang Liu, Xin-Yuan Miao et al. · 0 citations
Review Open access Aug 2026

Small-molecule inhibitors targeting the NLRP3 inflammasome: advances since mid-2023 and future perspectives.

The nod-like receptor protein 3 (NLRP3) inflammasome, a critical component of the innate immune system, governs the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 and thereby plays a central role in the pathogenesis of various inflammatory diseases. Its aberrant activation is closely lin...

D. Jia, Yun-Lei Hou, Yue Wu et al. · 0 citations

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