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Ping-Han Zhao

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Open access Oct 2026

Parkin deficiency rewires the genetic dependencies that govern neuronal survival

Loss-of-function mutations in PRKN cause early-onset Parkinson’s disease, and the prevailing model attributes the resulting neurodegeneration to failed mitochondrial quality control. We find that Parkin loss also rewires the genetic dependencies that govern neuronal survival. Isogenic Prkn-/-rat cortical neurons died a...

Shi-Jie Wang, D. Gulbranson, Beatrice Costa et al. · 0 citations

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