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Review Open access Jul 2026

Metabolic Reprogramming at the Tumor–Immune Interface in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) arises predominantly in chronic liver disease with a uniquely tolerogenic microenvironment. Immune checkpoint inhibitors (ICIs) have improved the prognosis of advanced HCC, yet most patients exhibit low response rates or therapeutic resistance due to the highly immunosuppressive tumor mic...

Wei-Ming Zhao, Ping Li · 0 citations

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