Author

Ping Liu

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Open access Sep 2026

Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial

Non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) can detect embryo chromosomal aneuploidy by analyzing the cell-free DNA in embryo culture media. However, evidence for its clinical efficacy is insufficient. In this investigator-initiated, multicenter, double-blind, randomised controlled trial, wome...

Jin Huang, Rong Li, L. Zeng et al. · Nature Communications · 0 citations

Sep 2026

Novel and recurrent TUBB8 variants cause irreversible meiotic spindle defects and refractory ART failure in Chinese women with oocyte maturation arrest.

Routine TUBB8 genetic screening is supported as a valuable diagnostic tool for unexplained recurrent OMA, facilitating early diagnosis, avoidance of futile ART cycles, and personalized reproductive counseling and expands the pathogenic mutational spectrum of TUBB8.

Xin-Jie Zhuang, Yue Li, Ying Lian et al. · Journal of Assisted Reproduc... · 0 citations

Aug 2026

Novel biallelic PATL2 variants causing predominant germinal vesicle arrest and recurrent ART failure: expanded mutational spectrum and evidence-based reproductive counseling guidance.

Biallelic pathogenic PATL2 variants constitute a major monogenic driver of refractory GV-predominant OOMD and complete recurrent ART failure and substantially expands the global spectrum of disease-causing PATL2 variants.

Xin-Jie Zhuang, Yue Li, Xin Qiu et al. · Journal of Assisted Reproduc... · 0 citations