Early esophageal squamous neoplasia and the microbiome: evidence, mechanisms, and early-detection potential
Esophageal squamous cell carcinoma (ESCC) remains a major cause of cancer mortality, largely because most patients are diagnosed at an advanced stage. High-grade intraepithelial neoplasia (HGIN) represents an important and clinically actionable precancerous stage in the ESCC pathway, during which timely detection and e...