Perioperative neurocognitive disorders (PND) are common neurological complications in elderly surgical patients, for which effective mechanism-based therapies remain lacking. This study identifies ferroptosis, an iron-dependent lipid peroxidation-driven cell death, as a key pathological process in PND, and pharmacologi...
Yiyan Sun, Yun Li, Fengping Zhang et al.· Cell Death and Differentiati...· 0 citations
This review summarizes the mechanisms by which microglia shape synaptic structure and function, including dynamic synaptic interactions, selective pruning, epigenetic regulation, extracellular matrix remodeling, metabolic adaptation, and communication with other glial cells.
Zheng Liu, Wu-lan Ao, Ai-Di Luo et al.· BMC Medicine· 0 citations
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