Disorganized bone collagen fibers in early-stage type 2 diabetes mellitus and its association with adipose tissue redistribution
Type 2 diabetes mellitus (T2DM) compromises bone quality and biomechanical integrity, driven by impaired microstructure, suppressed turnover, and collagen abnormalities. Crucially, this fragility occurs despite normal bone mineral density and may initiate early in the disease, underscoring the need for timely skeletal...