Author

Ping-Zhao Hu

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Open access Sep 2026

Exploratory Transcriptomic Profiling of Triple-Negative Breast Cancer Patient-Derived Organoids Following Treatment with Radiation Alone and in Combination with Polo-like Kinase 4 Inhibition

Identification of novel biomarkers in triple-negative breast cancer (TNBC), one of the most aggressive breast cancer subtypes, is of critical clinical importance. Although radiation treatment (RT) is a cornerstone of TNBC treatment, resistance to RT compromises its therapeutic efficacy. Combining RT with radiosensitizi...

Sugitha Janarthanan, Isabel Kannampuzha, Harjot Athwal et al. · Radiation · 0 citations

#graph neural networks Open access Sep 2026

Spatially guided translation from histology images to transcriptomic profiles using foundation model-driven contrastive learning

Spatial transcriptomics (ST) enhances single-cell RNA sequencing by revealing transcript distribution, offering critical insights into heterogeneous diseases such as breast cancer. However, the high cost and lengthy processes of generating high-quality ST data limit clinical application. Recent deep learning methods pr...

Zi-Huai Huang, Zi-Yang Xu, Ping-Zhao Hu · PLoS Computational Biology · 0 citations