Open access
Aug 2026
Discovery of a taxusin-mediated route to baccatin III enables its complete biosynthesis in engineered microbes
Taxol (paclitaxel) is a frontline anticancer drug widely applied for the treatment of breast, ovarian and lung cancers. Currently, its supply mainly relies on the semi-synthesis using baccatin III from Taxus plants. Heterologous biosynthesis of baccatin III in microorganisms offers a promising solution to alleviate glo...
Chengshuai Yang, Zhenhua Li, Linjie Yu et al.
· bioRxiv · 0 citations