Staphylococcus aureus biofilm infection impairs efferocytosis in wound-macrophages via induction of a MARCOhiMERTKlo subset.
Chronic, non-healing wounds are sustained by Staphylococcus aureus biofilms, yet how biofilm reprograms the immune cells tasked with resolving injury has remained unclear. We show that biofilm-derived soluble cues, not bacterial contact, generate a previously undescribed biofilm-associated macrophage (BAM) subset marke...