Regulation of Glutathione Peroxidase 4 in Diabetic Retinopathy
Oxidative stress-mitochondrial dysfunction plays a central role in diabetic retinopathy. Glutathione peroxidase 4 (GPx4), a key antioxidant enzyme that detoxifies lipid peroxides, is inhibited in diabetes, but the mechanism underlying its inhibition is unclear. Here, we have investigated the role of ubiquitination in r...