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Author

Poojitha Sai Potharaju

2 papers indexed here

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Open access Sep 2026

DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis.

Amyloid aggregates of α-Synuclein are hallmarks of Parkinson's disease (PD) and related neurodegenerative disorders. Literature suggests that mRNA G-quadruplexes (rG4s) bind to α-Synuclein, facilitating its amyloidogenesis. In parallel, α-Synuclein interacts with RNA-binding proteins (RBPs) within cytosolic RNA-protein...

Aanchal Jain, Shreya Tripathi, Cheshta Agarwal et al. · 0 citations
Open access Sep 2026

MAVS maintains mitochondrial import competence and also limits RNA virus replication independently of interferon signaling

ABSTRACT Intrinsic, cell-autonomous antiviral defenses can restrict infection without involving paracrine interferon (IFN) programs. Previous studies have demonstrated the importance of intact mitochondrial homeostasis in antiviral immunity. Mitochondrial antiviral signaling (MAVS) protein is a critical adaptor molecul...

Vishal Sah, Poojitha Sai Potharaju, Karthika S. Nair et al. · 0 citations

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