Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, synaptic dysfunction, and neuronal loss. Emerging evidence identifies tau acetylation as a crucial post-translational modification that contribute significantly to tauopathies associated pathology in AD. Aberrant ta...
K. Basavaraju, Poornima Priyadarshini· Biochemical and Biophysical...· 0 citations
Understanding the molecular mechanisms that link alcohol consumption, acetylation dysregulation, and tau pathology has significant therapeutic potential in AD treatment.
K. Basavaraju, D. K. Harshitha, Poornima Priyadarshini· Neuroscience· 0 citations
The development of standardized cell culture models in the SH-SY5Y neuronal system will be crucial to evaluating the therapeutic potential of this synergetic inhibition strategy, thereby restoring ubiquitination and promoting tau degradation.
Basavaraju K. C., Harshitha D. K., Poornima Priyadarshini· Methods in Enzymology· 0 citations
Understanding the metabolic pathways that drive tau acetylation may offer new therapeutic targets aimed at restoring neuronal energy balance, re-establishing acetylation homeostasis, and potentially slowing the progression of AD.
Basavaraju K. C., Poornima Priyadarshini· International review of neur...· 0 citations
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