Harnessing Yarrowia lipolytica as a platform for animal-free and secretory production of human lactoferrin.
Human lactoferrin (hLF) is an iron-binding glycoprotein with important nutritional and therapeutic functions. Microbial production of recombinant hLF offers a scalable and animal-free alternative to extraction from milk, but efficient secretion remains a major challenge. Here, we developed Yarrowia lipolytica as a micr...