Pouria A. Mistani

Spatially Resolved Nucleated Polymerization: A Free-Boundary Model of Protein Aggregation in Concentrated Solutions

Kinetic models of protein aggregation describe populations by size, not by spatial organization or morphology. We extend Lumry-Eyring nucleated polymerization to a model in which the monomer is a density field and each aggregate is a region bounded by a level set. Growth is a flux condition on the available sites of a...