Open access
Oct 2026
FDX1-independent non-canonical cuproptosis establishes a parallel mitochondria-centric death program
Copper is an essential redox cofactor required for mitochondrial respiration and antioxidant defense, yet its dysregulation creates a therapeutic vulnerability that can be exploited by copper active agents. Elesclomol and neocuproine are two potent copper active compounds, but whether they induce the same form...
Jan Bachmann, Maria-Grazia Molvetti, Anđelija Trajković et al.
· Molecular Cancer · 0 citations