Prachi Singh

Synthesis, In-Vitro, and In-silico analysis of Repurposed Substituted 2,7-Dimethylimidazo [1,2-a]Pyridine-3-Carboxamide based α-Amylase inhibitors via docking, MMGBSA, dynamics simulation techniques and pharmacokinetic evaluation

In-silico ADME studies indicated favorable pharmacokinetic properties, including high gastrointestinal absorption, low TPSA, BBB permeability, and compliance with Lipinskis rule, while toxicity prediction suggested acceptable safety profiles for the synthesized derivatives, highlighting their potential as promising α-a...